Journal: Drug Delivery and Translational Research

Article Title: Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs

doi: 10.1007/s13346-022-01133-6

Figure Lengend Snippet: Hot-melt extruder and FDM 3D printer used in current study. a HAAKE™ MiniLab II Micro Compounder utilized for fabricating medical-grade polyurethane filament for FDM 3D printing. b Schematic illustration of the printing process involving some of the key components of lab-developed FDM 3D printer utilized in the present study

Article Snippet: In the present study, we employed FDM 3D printing to create significantly smaller release pores at mesoscale (200–500 μm) on the reservoir IVR segments (Figs. – ) to restrict the diffusion of IgG and small fragment of gp120.

Techniques:

Journal: Drug Delivery and Translational Research

Article Title: Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs

doi: 10.1007/s13346-022-01133-6

Figure Lengend Snippet: SEM imaging of FDM 3D printed HP-60D-35 segments and macaque-size IVR. Panels ( A – G ) demonstrated the printed segment with different perimeter shells incrementally from 1 to 7 shells (ro/ri ratios ranging from 1.12 to 2.61). Panel ( H ) depicts an example RCM thickness measurement of a printed segment with 3 shells. A full-size macaque reservoir-IVR can be directly printed as shown in panel ( I ) with adequate flexibility demonstrated in panel ( J )

Article Snippet: In the present study, we employed FDM 3D printing to create significantly smaller release pores at mesoscale (200–500 μm) on the reservoir IVR segments (Figs. – ) to restrict the diffusion of IgG and small fragment of gp120.

Techniques: Imaging

Journal: Drug Delivery and Translational Research

Article Title: Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs

doi: 10.1007/s13346-022-01133-6

Figure Lengend Snippet: In vitro biocompatibility evaluations of FDM 3D printed ATPU-75A segments. ( A ) MTS assay was performed to determine the cell viability. Data is normalized to the negative control and expressed as mean ± SD, n = 4. Cell culture in regular medium was used at negative control. 1 M acrylamide dissolved in normal cell culture medium was used to induce cell death as positive control. ( B ) IL-1β, ( C ) IL-6, and ( D ) IL-8 secretions into the culture medium were determined using sandwich ELISA assays. Plain culture medium was used as negative control. 200 µg/mL of nonoxynol-9 or 50 µg/mL of lipopolysaccharide-treated cells were used as positive controls for IL-1β and IL-6/IL-8, respectively. P, positive control. N, negative control. Data expressed as mean ± SD, n = 4. * p < 0.05 versus negative control

Article Snippet: In the present study, we employed FDM 3D printing to create significantly smaller release pores at mesoscale (200–500 μm) on the reservoir IVR segments (Figs. – ) to restrict the diffusion of IgG and small fragment of gp120.

Techniques: In Vitro, MTS Assay, Negative Control, Cell Culture, Positive Control, Sandwich ELISA

Journal: Micromachines

Article Title: Process Study on 3D Printing of Polymethyl Methacrylate Microfluidic Chips for Chemical Engineering

doi: 10.3390/mi16040385

Figure Lengend Snippet: The simulation diagram of the temperature situation and thermal stress distribution with the 3D-printed PMMA process. ( a ) Temperature situation. ( b ) Thermal stress distribution.

Article Snippet: During the preliminary phase of process development, FDM 3D printing of PMMA filament was simulated using COMSOL Multiphysics software v5.5, a finite element analysis software platform for multiphysics computational modeling.

Techniques:

Journal: Micromachines

Article Title: Process Study on 3D Printing of Polymethyl Methacrylate Microfluidic Chips for Chemical Engineering

doi: 10.3390/mi16040385

Figure Lengend Snippet: The warping diagram material additive with the FDM 3D-printed PMMA process. ( a ) Printing material warping deformation with the numerical simulation system. ( b ) Printing material warping deformation with an actual machining system. The red triangle represents the degree of horizontal warping of the printed single-layer material relative to the platform. ( c ) The PMMA material warps with three layers printing along the vertical route in the Y -axis direction. ( d ) The morphology of optimally printed three-layer PMMA materials, warping and delamination suppression via platform temperature control (95 °C), and brim adhesion strategy: synergistic effects in 3D-printed PMMA microfluidic chip fabrication.

Article Snippet: During the preliminary phase of process development, FDM 3D printing of PMMA filament was simulated using COMSOL Multiphysics software v5.5, a finite element analysis software platform for multiphysics computational modeling.

Techniques: Control

Journal: Micromachines

Article Title: Process Study on 3D Printing of Polymethyl Methacrylate Microfluidic Chips for Chemical Engineering

doi: 10.3390/mi16040385

Figure Lengend Snippet: The profile of a microfluidic chip with a single 3D-printed molding technique. ( a ) Leakage-free 3D-printed microfluidic chips enabled by gyroid infill pattern: structural integrity enhancement through TPMS design. ( b ) Fluid leakage in 3D-printed chips with twelve other infill patterns (e.g., rectilinear, triangular, and hexagonal): structural deficiencies from reduced integrity and mechanical strength. ( c ) Optical clarity and structural homogeneity of 2-mm-thick 3D-printed PMMA microfluidic chips: transparency benchmarking against a microreactor and a 50-cent CNY coin for scale reference.

Article Snippet: During the preliminary phase of process development, FDM 3D printing of PMMA filament was simulated using COMSOL Multiphysics software v5.5, a finite element analysis software platform for multiphysics computational modeling.

Techniques:

Journal: Micromachines

Article Title: Process Study on 3D Printing of Polymethyl Methacrylate Microfluidic Chips for Chemical Engineering

doi: 10.3390/mi16040385

Figure Lengend Snippet: The optimized result of PMMA microchannel with an orthogonal method. ( a ) A factor response figure of the orthogonal method. Ai was the factor of nozzle temperature, Bi was the factor of printing speed, and Ci was the factor of layer height. The line was steeper; the influence of the factor was greater. ( b ) Roughness value with optimized 3D-printed parameter. ( c ) Microchannel profile waviness with optimized 3D-printed parameter. The waviness characterized the microchannel surface planarity. ( d ) The micrograph of the optimized microchannel profile using metallographic microscopy (scale bar: 100 μm).

Article Snippet: During the preliminary phase of process development, FDM 3D printing of PMMA filament was simulated using COMSOL Multiphysics software v5.5, a finite element analysis software platform for multiphysics computational modeling.

Techniques: Microscopy

Journal: Materials

Article Title: Mechanical Properties of Fused Deposition Modeling of Polyetheretherketone (PEEK) and Interest for Dental Restorations: A Systematic Review

doi: 10.3390/ma15196801

Figure Lengend Snippet: The printing parameters and mechanical properties of FDM 3D-PEEK.

Article Snippet: They compared milled PEEK (Juvora dental disc) with four types of FDM 3D-printed PEEK (Essentium PEEK, Ketaspire PEEK, Vestakeep i4G and Victrex PEEK 450G).

Techniques: Injection